The amount and diversity of high-throughput data that are produced within the RPA Systems Biology offers tremendous opportunities to enhance our molecular understanding of host-microbiome interactions. One of the challenges is the integration and interpretation of large-scale omics data in ways that provides insights into the role of microbes on their hosts. The bioinformaticians of the RPA Systems Biology lend support and guidance in the implementation and development of bioinformatics pipelines that enable our scientist to identify molecular mechanisms underlying complex biological interactions.