Inflammatory bowel disease (IBD), including Crohn’s Disease and ulcerative colitis, is a group of chronic diseases in the gastro-intestinal tract that already affects millions of people worldwide while the incidence is still increasing. The cause of IBD is thought to be an interplay between genetic predisposition and environmental triggers such as diet, antibiotic exposure and infections which shape the gut microbiome into a state of dysbiosis. Subsequently, the state of dysbiosis is shown to affect the severity of the disease. Current treatments for IBD mainly focus on reducing inflammation and symptom relief rather than curing the disease and the group of non-responders remains large. The need for new treatment is high and therefore more insight in the development and course of the disease is needed.
Scientist involved in this project
- Thesis: Analyzing and visualizing molecular events in bacterial spore germination
J. Wen, 7 October 2020, UvA-DARE (Digital Academic Repository)
- Visualization of Germination Proteins in Putative Bacillus cereus Germinosomes
Wang, Y.; de Boer, R.; Vischer, N.; van Haastrecht, P.; Setlow, P.; Brul, S. Int. J. Mol. Sci. 2020, 21, 5198.
- Integrative Analysis of Proteome and Transcriptome Dynamics during Bacillus subtilis Spore Revival
Bhagyashree Swarge, Wishwas Abhyankar, Martijs Jonker, Huub Hoefsloot, Gertjan Kramer, Peter Setlow, Stanley Brul, Leo J. de Koning. mSphere Aug 2020, 5 (4) e00463-20; https://doi.org/10.1128/mSphere.00463-20
- Investigating Synthesis of the MalS Malic Enzyme during Bacillus subtilis Spore Germination and Outgrowth and the Influence of Spore Maturation and Sporulation Conditions
Swarge, B., Nafid, C., Vischer, N., Kramer, G., Setlow, P., & Brul, S. (2020). mSphere, 5(4), e00464-20. https://doi.org/10.1128/mSphere.00464-20