Dental plaque is a biofilm and is an important indicator of oral health. When left untreated, it can lead to inflammation of the gums, also known as gingivitis. A biofilm is a local organization of microbes that is attached to a surface – in this case the tooth surface. The exact mechanics that allow for the formation of dental plaque are unclear.
We aim to elucidate the complex interaction between microbiome and metabolome using Parallel Factor Analysis. This method is able to describe the bits in the data where the variation is highest, also over time. By comparing the models, we can form hypotheses on the microbiome-metabolome interactions that occur.
Scientists involved in this project
Roel van der Ploeg
Egija Zaura (ACTA)
Monique van der Veen (ACTA)
Bart Keijser (TNO)
In coorporation with
Acadamsich Centrum Tandheelkunde Amsterdam (ACTA)
Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek (TNO)
- Dynamics of red fluorescent dental plaque during experimental gingivitis–A cohort study
van der Veen MH, Volgenant CM, Keijser B, Ten Cate JB, Crielaard W., J Dent. 2016 May;48:71-6. Epub 2016 Feb 24. PMID: 26921667. doi: 10.1016/j.jdent.2016.02.010.
- Effect of experimental gingivitis induction and erythritol on the salivary metabolome and functional biochemistry of systemically healthy young adults
Prodan, A., Imangaliyev, S., Brand, H.S. et al. Metabolomics 12, 147 (2016). https://doi.org/10.1007/s11306-016-1096-4