The overall aim of the project is to understand the interplay between microbial patterns with depression in adolescents from an urban setting using a complexity approach, whereby the gut microbiome is theorized as both a readout of environmental influences, as well as a modifiable biological factor in depression.
This will be done in 3 parts:
1 Discovery phase, to investigate the impact of adolescent depression on individual and group microbial patterns over time. In order to this, two projects have started: (a) Review into the changeability of the microbiome in depression. (b) Analysis of a large-scale dataset (Helius) into the relation between adverse childhood events and microbiome.
2 Mechanism exploration phase, to analyze functional microbiota parameters in conjunction with the known host physiology. Taking the results from the microbiome sequencing analysis, we will use preclinical models to investigate the function of certain microbiota and metabolites, with a focus on butyrate (year 2-3).
3 Proof of concept intervention phase, to investigate the effectiveness of microbial metabolite intervention on depressive symptoms. Simultaneously, we will perform a randomized clinical trial with butyrate to study the effect on depressive symptoms in urban adolescents (year 1-4).
Scientist involved in this project
Vera Korenblik
Stanley Brul
Aniko Korosi
Anja Lok (Amsterdam UMC)
Claudi Bockting (UMH)
Paul Lucassen
Funded by
University of Amsterdam Research Priority Area Urban Mental Health
Publications
- Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review
Vera Korenblik, Marlies E.Brouwer, Aniko Korosic, Damiaan Denys, Claudi L.H. Bockting, Stanley Brul and Anja Lok. Neuropharmacology, Volume 223, 2023, 109318, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2022.109318.
- Time-Resolved Proteomics of Germinating Spores of Bacillus cereus.
Gao, X.; Swarge, B.N.; Roseboom, W.; Setlow, P.; Brul, S.; Kramer, G. Int. J. Mol. Sci. 2022, 23, 13614. https://doi.org/10.3390/ijms232113614
- The Role of the Gut Microbiota in the Effects of Early-Life Stress and Dietary Fatty Acids on Later-Life Central and Metabolic Outcomes in Mice.
Reemst K, Tims S, Yam KY, Mischke M, Knol J, Brul S, Schipper L, Korosi A. mSystems. 2022 Jun 13:e0018022. doi: 10.1128/msystems.00180-22.